{"id":1167,"date":"2022-08-08T00:35:57","date_gmt":"2022-08-08T00:35:57","guid":{"rendered":"https:\/\/herriottabuteau.org\/staging\/5350\/?page_id=1167"},"modified":"2022-08-19T00:01:10","modified_gmt":"2022-08-19T00:01:10","slug":"publications","status":"publish","type":"page","link":"https:\/\/herriottabuteau.org\/staging\/5350\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n
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Publications<\/h2>\n\n\n\n

U.S. Patents<\/strong><\/p>\n\n\n\n

Dr. Tabuteau is the inventor on more than 290 issued U.S. patents. These patents may be viewed on the U.S. Patent and Trademark Office (USPTO) website by clicking here [link: https:\/\/patft.uspto.gov\/netacgi\/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=0&f=S&l=50&TERM1=Tabuteau&FIELD1=&co1=AND&TERM2=Herriot&FIELD2=&d=PTXT].<\/p>\n\n\n\n

Select Scientific Publications and Presentations<\/strong><\/p>\n\n\n\n

  1. Tabuteau H<\/strong>, Jones A, Anderson A, Jacobson M, Iosifescu DV. Effect of AXS-05 (Dextromethorphan-Bupropion) in Major Depressive Disorder: A Randomized Double-Blind Controlled Trial. Am J Psychiatry<\/em>. 2022 May 18.<\/li>
  2. Iosifescu DV, Jones A, O’Gorman C, Streicher C, Feliz S, Fava M, Tabuteau H.<\/strong> Efficacy and Safety of AXS-05 (Dextromethorphan-Bupropion) in Patients With Major Depressive Disorder: A Phase 3 Randomized Clinical Trial (GEMINI). J Clin Psychiatry<\/em>. 2022 May 30;83(4).<\/li>
  3. O’Gorman C, Jones A, Iosifescu DV, Thomas Z, Tabuteau H<\/strong>. Rapid Effects of AXS-05, an Oral NMDA Receptor Antagonist, in Major Depressive Disorder: Results From Two Randomized, Double-Blind, Controlled Trials. Biological Psychiatry<\/em>. 2021;89:S244.<\/li>
  4. Jones A, O’Gorman C, Anderson A, Tabuteau H<\/strong>. Efficacy and Safety of AXS-05, an Oral NMDA Receptor Antagonist, in the Prevention of Relapse in Patients With Treatment-Resistant Depression: Results From MERIT, a Double-Blind, Placebo-Controlled Relapse Prevention Trial. Neuropsychopharmacology<\/em>. 2021;46(SUPPL 1):201-201.<\/li>
  5. O’Gorman C, Jones A, Anderson A, Jacobson M, Feliz S, Streicher C, Thomas Z, Tabuteau H<\/strong>. Rapid Antidepressant Effects and MADRS Core Symptom Improvements With AXS-05, an Oral NMDA Receptor Antagonist, in Major Depressive Disorder: Results From Two Randomized, Double-Blind, Controlled Trials. Neuropsychopharmacology<\/em>.2021;46(SUPPL 1):201-202.<\/li>
  6. O’Gorman C, Jones A, Cummings JL, Tabuteau H<\/strong>. Efficacy and safety of AXS\u201005, a novel, oral, NMDA\u2010receptor antagonist with multimodal activity, in agitation associated with Alzheimer\u2019s disease: Results from ADVANCE\u20101, a phase 2\/3, double\u2010blind, active and placebo\u2010controlled trial: Developments in clinical trials and cognitive assessment. Alzheimer’s & Dementia.<\/em> 2020; 16(e047684).<\/li>
  7. A Jones, R McIntyre, M Jacobson, C Streicher, Z Thomas, H Tabuteau<\/strong>. Impact of AXS-05, an Oral NMDA Receptor Antagonist, on Anhedonic Symptoms in Major Depressive Disorder. American Society of Clinical Psychopharmacology (ASCP), June 2022.<\/li>
  8. A Jones, C Streicher, Z Thomas, H Tabuteau<\/strong>. Improvement in Anxiety Symptoms in Depressed Patients Treated with AXS-05 (Dextromethorphan Bupropion): Results from the EVOLVE Open label, Long term Study. American Society of Clinical Psychopharmacology (ASCP), June 2022.<\/li>
  9. A Jones, C Streicher, Z Thomas, H Tabuteau<\/strong>. AXS-05 (Dextromethorphan Bupropion) Improves Depressive Symptoms and Functioning in Patients with One Prior Treatment Failure: Results from the EVOLVE Long Term, Open Label Study. American Society of Clinical Psychopharmacology (ASCP), June 2022.<\/li>
  10. A Jones, C O\u2019Gorman, C Streicher, S. Feliz, D Iosifescu, H Tabuteau<\/strong>. Efficacy and Safety of AXS-05, an Oral NMDA Receptor Antagonist with Multimodal Activity, in Major Depressive Disorder: Results From the GEMINI Trial. American Psychiatric Association (APA), May 2021.<\/li>
  11. A Jones, C O\u2019Gorman, H Tabuteau<\/strong>. Sustained Effects of AXS-05, an Oral NMDA Receptor Antagonist, in Treatment Resistant Depression Patients: Results from the COMET-TRD Trial. American Society of Clinical Psychopharmacology (ASCP), June 2021.<\/li>
  12. C O\u2019Gorman, A Jones, D Iosifescu, H Tabuteau<\/strong>. Efficacy and Safety of AXS-05, an Oral NMDA Receptor Antagonist with Multimodal Activity, in Major Depressive Disorder: Results from the GEMINI Phase 3, Double-Blind, Placebo-Controlled Trial (Oral Presentation). American Society of Clinical Psychopharmacology (ASCP), May 2020.<\/li>
  13. A Anderson, D Iosifescu, M Jacobson, A Jones, K Kennon, C O\u2019Gorman, S Stahl, H Tabuteau<\/strong>. Efficacy and Safety of AXS-05, an Oral NMDA Receptor Antagonist with Multimodal Activity, in Major Depressive Disorder: Results of a Phase 2, Double-Blind, Active-Controlled Trial. ASCP. Scottsdale, AZ. May 28-31, 2019.<\/li>
  14. C O’Gorman, A Jones, J Cummings, H Tabuteau<\/strong>. Efficacy and Safety of AXS-05, a Novel Oral NMDA Receptor Antagonist with Multimodal Activity, in the Treatment of Alzheimer’s Disease Agitation: Results of the ADVANCE-1 Trial (Oral Presentation). Clinical Trials on Alzheimer’s Disease (CTAD), November 2020.<\/li>
  15. C O’Gorman, D Iosifescu, A Jones, K Kennon, R Niecestro, G Papakostas, H Tabuteau<\/strong>. Clinical Development of AXS-05 for Treatment Resistant Depression and Agitation Associated with Alzheimer’s Disease.  American Psychiatric Association (APA) May 2018.<\/li>
  16. Z Thomas, R Lipton, A Jones, A Chhabra, S Alter, H Tabuteau<\/strong>. Identifying Areas of Unmet Need among Migraineurs with Inadequate Response to Acute Therapies: Results from the MOMENTUM trial. American Headache Society (AHS) June 2022.<\/li>
  17. Jones A, Tepper SJ, Thomas Z, Tabuteau H.<\/strong> Efficacy of AXS-07 (MoSEIC (TM) meloxicam and rizatriptan) in patients with risk factors for inadequate response to acute migraine medications. Headache<\/em> 2022;62:142-143.<\/li>
  18. A Jones, C O\u2019Gorman, S Tepper, H Tabuteau<\/strong>. Efficacy and Safety of AXS-07(MoSEIC\u2122 Meloxicam\/Rizatriptan) in the Acute Treatment of Migraine: Results from the INTERCEPT Phase 3 Trial. American Headache Society (AHS) June 2021.<\/li>
  19. A Jones, C O\u2019Gorman, R Lipton, S Tepper, H Tabuteau<\/strong>. Efficacy and Safety of AXS-07 for the Acute Treatment of Migraine: Results from the MOMENTUM (Maximizing Outcomes in Treating Acute Migraine) Phase 3 Randomized, Double-blind, Active- and Placebo-controlled Study. American Academy of Neurology (AAN) Science Highlights platform, September 2020.<\/li>
  20. O’Gorman C, Jones A, Tepper SJ, Askew C, Lipton RB, Tabuteau H<\/strong>. Efficacy and Safety of AXS-07 (MoSEIC Meloxicam-Rizatriptan) for the Acute Treatment of Migraine: Results from the MOMENTUM Phase 3, Randomized, Double-blind, Active- and Placebo controlled Trial. The Journal of Headache and Pain.<\/em> 2021; 22(Suppl 1):AL055.<\/li>
  21. Jones A, O’Gorman C, Askew C, Tabuteau H<\/strong>. Long Term Efficacy and Safety of AXS-07 (MoSEIC (TM) Meloxicam-Rizatriptan) for the Acute Treatment of Migraine: Results from the MOVEMENT Phase 3 Trial. Annals of Neurology<\/em>. 2021;90:S134-S134.<\/li>
  22. Jones A, O’Gorman C, Tepper SJ, Lipton RB, Tabuteau H.<\/strong> Efficacy and Safety of AXS-07 (MoSEIC Meloxicam\/Rizatriptan) in the Acute Treatment of Migraine: Results from the INTERCEPT Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial. Annals of Neurology<\/em>. 2020;88: S150-S151.<\/li>
  23. O’Gorman C, Jones A, Thorpy MJ, Tabuteau H<\/strong>. Efficacy and Safety of AXS-12 in the Treatment of Narcolepsy: Results from a Phase 2, Double-Blind, Placebo-Controlled, Crossover Trial. Sleep<\/em>. 2020; 43(Supplement_1):A281-A281.<\/li>
  24. C O\u2019Gorman, A Jones, A Chhabra, M Thorpy, H Tabuteau<\/strong>. Efficacy and Safety of AXS-12 in the treatment of Narcolepsy: Results from a Phase 2, Double-Blind, Placebo-Controlled, Crossover Trial. Meeting of the Associated Professional Sleep Societies (SLEEP), August 2020.<\/li><\/ol>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/pagebuilder.php","meta":{"zakra_page_container_layout":"stretched","zakra_page_sidebar_layout":"no_sidebar","zakra_remove_content_margin":true,"zakra_sidebar":"customizer","zakra_transparent_header":"customizer","zakra_logo":0,"zakra_main_header_style":"default","zakra_menu_item_color":"","zakra_menu_item_hover_color":"","zakra_menu_item_active_color":"","zakra_menu_active_style":"","zakra_page_header":true,"nf_dc_page":"","footnotes":""},"class_list":["post-1167","page","type-page","status-publish","hentry"],"yoast_head":"\nPublications - HerriotTabuteauMD<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/herriottabuteau.org\/staging\/5350\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - 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